Top 10 Menopause Supplements for Symptom Relief

Published December 20, 2021.
Our team independently researches and recommends the best products for women's health. We publish unbiased reviews and are not influenced by payments we may receive from advertising partners.

The number of over-the-counter treatments available to women experiencing menopause can be overwhelming. While some address a range of symptoms, others provide targeted relief of specific problems. Thanks to modern science, we now have a great choice of over-the-counter pills and tablets to choose from, including plenty of superb clinically-proven supplements, many of which use all-natural ingredients while avoiding allergens and hormones.
We’ve researched and tested some of the best certified and most popular supplements to narrow it down and relieve particular menopause symptoms.
A Quick Look at Our Top 10 Menopause Supplements for Symptom Relief
- Best overall over-the-counter menopause treatment: Internal Harmon
- Best for energy and mood: Estroven
- Best vegetarian perimenopause all rounder: Nature's Way
- Best beauty choice: Womaness
- Best for vaginal irritation: EQUELLE
- Best value for money: Windsor Botanicals
- Fastest improvement results: Remifemin
- Best for night sweats: Amberen
- Best for perimenopause: Amberen
- Best for weight loss in perimenopause: Estroven
What Are the Worst Menopause Symptoms?
As a result of menopause, women may experience a number of symptoms. Though they can vary greatly, most women experience a few of the following symptoms:
- Difficulty sleeping
- Hot flushes
- Mood swings
- Forgetfulness
- Urinary incontinence and urinary tract infections
- Vaginal dryness
- Low libido
- Hair loss
- Pain in joints
- Fatigue
- Digestive problems
- Headaches
How We Chose Our Products
With several factors at play, we looked at the following:
- Safety to take long-term - Effectiveness in treatment - Quality of ingredients - Value for money
AskIris’ Picks for the Top 10 Menopause Supplements
Best overall over-the-counter menopause treatment
With a 60-day money-back guarantee, several ‘swear by it’ reviews and all organic ingredients, this is our top all-round choice for treating menopause. Clinically tested components such as GeniVida, a non-soy genistein, along with Black Cohosh and B vitamins have been combined into an inimitable prevention treatment for hot flushes, night sweats, and stress.
Organic, gluten-free, hormone free, and caffeine-free, this is a popular and reliable over-the-counter supplement for menopausal women with specific dietary needs or allergies.
Internal Harmony Pros and Cons
Pros
- 60-day money-back guarantee
- Organic ingredients
- Clinically tested
- Hormone-free
- Gluten-free
- Caffeine-free
Cons
- Some report headaches at the start of treatment
Best for energy and mood
This well-known brand offers an impressive safety profile for their treatment, as well as showing excellent efficacy in treating a number of symptoms. Women reported noticeable reduction in hot flushes, as well as significant improvement in sleep quality, energy, mood, bladder health, and libido.
It has shown results in as little as 28 days.
Estroven Pros and Cons
Pros
- Proven safety
- Treats numerous symptoms
- May work faster than other supplements (in 28 days)
- Boosts libido
- Hormone-free
- Gluten-free
- Improves sleep, energy, and mood
Cons
- Contains estrogen which may cause side effects such as irritability
Best vegetarian perimenopause all-rounder


Comprehensive vegetarian treatment for perimenopause
Buy NowPrice
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$19
No. of capsules
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60 (30-day supply)
This is a great vegetarian and gluten-free supplement for women experiencing perimenopause. Known for its efficacy in dealing with hot flushes and night sweats but also with weight-management and mood, this is a strong contender as an all-rounder over-the-counter treatment.
It also boasts great assistance with menstrual symptoms and irritability in particular. Some minor side effects such as acne have been reported.
Nature's Way Pros and Cons
Pros
- Vegetarian
- Effective treatment of several symptoms
- Known for weight management
- Hormone-free
- Gluten-free
Cons
- May cause acne in some women
Best beauty choice
A popular tried and tested option among women experiencing menopause symptoms such as brittle nails, thinning hair, and inflammatory skin conditions. Clinical trials indicate significant decrease in wrinkles.
Active Glow is hormone-free and plant-based.
Womaness Pros and Cons
Pros
- Hormone-free
- Plant-based
- Proven to strengthen hair, skin, and nails
- Works on wrinkles
- Clinically-tested
Cons
- Does not necessarily improve other menopausal symptoms
Best for vaginal irritation


Hormone-free all rounder for improving vaginal irritation
Buy NowPrice
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$45
No. of capsules
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120 (30-day supply)
Clinical tests revealed that Equelle’s remedy alleviated vaginal irritation, hot flushes, and improved quality and length of sleep.
This supplement is hormone-free, but features a plant-based ingredient, S-equol, which acts similarly to estrogen in assisting with symptoms caused by menopause.
EQUELLE Pros and cons
Pros
- Provides relief for vaginal problems
- Mimics estrogen
- Hormone-free
- Clinically-tested
Cons
- Mixed reviews
- Large pills may be difficult to swallow for some
- Higher price than most supplements
Best value for money


Vegetarian supplement including vitamins assists weight loss
Buy NowPrice
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$19
No. of capsules
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60 (30-day supply)
Windsor’s offering presents an appealing combination of health-boosters. Containing numerous high doses of vitamins and minerals as well as other natural ingredients, it assists with most menopause symptoms and improves sleep and energy.
This treatment is also known for being cruelty-free and many users report significant assistance with weight management, all at an attractive price.
Windsor Botanicals Pros and Cons
Pros
- Vegetarian
- Cruelty free
- Treats hot flushes effectively
- Assists weight loss
- Cruelty-free
- Great price
Cons
- May cause digestive problems in some women
Fastest improvement results
Many women using Remifemin have reported improvement in sleep, libido, and mood and a noticeable reduction in hot flushes. The fact that this treatment is gluten and hormone free adds appeal. It is also unlikely to cause any stomach upset even when taken without food.
Trials indicate that improvements can be seen in a few weeks and some women report improvement after a few days
Remifemin Pros and Cons
Pros
- Fast working
- Reduces number and severity of hot flushes
- Gluten-free
- Boosts libido
Cons
- some reports of elevated liver enzymes
Best for night sweats
Safe, clinically tested, and effective in treatment for symptoms of menopause, this supplement from Amberen is a trusted choice for women going through this difficult chapter. 78% of women experienced improvement in night sweats while taking it.
This medication, which combines succinates, amino acids, vitamin E, and minerals, showed no negative side effects at trials.
Amberen Pros and Cons
Pros
- Lessens number and severity of hot flushes and night sweats
- Improves mood
- Boosts energy
- Clinically-tested
- Also offers 60 and 90-day supplies on Amazon
Cons
- Contains MSG
- Higher price than most supplements
Best for perimenopause
Rigorously and widely tested through various clinical trials, the perimenopause treatment from Amberen attracts women with its great numbers. 74% of perimenopausal women reported improved menstrual regularity and 86% noticed more energy.
While this supplement is a little more pricey than some of the others, it may be worth the cost.
Amberen Pros and Cons
Pros
- Balances hormones and helps to regulate cycle
- Efficacy in reducing hot flashes
- Improves mood
- Boosts energy
Cons
- Higher price than other supplements
- Contains MSG
Best for weight loss in perimenopause
Glowing reports of regular menstrual cycles returning, hot flashes disappearing, and significant weight loss make Estroven a smart choice among perimenopausal budget-conscious shoppers, and those who have lactose or gluten allergies. This product is also hormone free.
A unique formula assists with metabolism and serotonin balance.
Estroven Pros and cons
Pros
- Assists weight loss
- Helps to regulate cycle
- Boosts serotonin
- Lactose-free
- Hormone-free
- Gluten-free
Cons
- Can take a month or more to start working
Final Verdict: Which Menopause Supplement Is the Best?
Every woman is different and experiences different menopause symptoms. While, for the most part, it can be difficult to predict how a woman’s body might respond to any supplement, the money-back guarantee, consistency in symptom management, and value for money of Multi-Symptom Menopause Relief by Internal Harmony makes it our winner for over-the-counter menopause treatment.