Top 10 Creams for Relieving Menopause Symptoms


Published December 27, 2021.
Our team independently researches and recommends the best products for women's health. We publish unbiased reviews and are not influenced by payments we may receive from advertising partners.

Menopause causes so many unpleasant symptoms that need relief. Luckily, we have gathered some safe, natural, and effective topical treatments that are sure to provide that relief. We hope to help make your life better with this carefully curated list of our best menopause creams.
The treatments below include the top hormone creams, as well as some hormone-free lotions, and several healing options for vaginal dryness. They have all been clinically tested and tried by many women to treat a variety of different symptoms.
A Quick Look at Our Top 10
- Best overall: Estro-Life by SM Nutrition
- Best for balance: Pro-Relief Balancing Cream by Imagine Dermatology
- Best for vaginal discomfort: Premium Natural Vulvacare by Pharmapulse
- Best for sensitive skin: Vmagic by Medicine Mama’s Apothecary
- Safest option: Progresto-Life by SM Nutrition
- Best vegan option: Estrogen Cream for Menopause Relief by Joellyne Naturals
- Best value for money: Progesta-Care by Life-Flo
- Best for hot flashes: Wild Yam Cream by Swanson
- Best hormone-free option: Intimate Moisture Cream by Membrasin
- Best for mood support: Progesterone from Wild Yam by NOW Solutions
Do Creams Really Work for Menopause?
Creams can address a wide range of symptoms locally, which can provide more instantaneous relief than pills and tablets for certain problems. Research into the effectiveness of using creams for relieving symptoms of menopause is extremely limited. Existing studies have found conflicting results, though most agree that some women respond better to this type of therapy than others.
What this means for you is that it's unclear whether menopause creams would definitively work for your situation or not. You may respond well, poorly, or not at all. However, you can find solace in knowing that the products we've selected are well-regarded by many different women who experienced benefits without side effects.
How We Chose Our Products
When choosing all of our products, these are the things we looked at and considered:
- Safety for long-term use
- Quality ingredients
- Clinical trials
- Effectiveness for specific symptoms
- Additional benefits
- Affordable price
AskIris’ Picks for the Top 10 Menopause Creams
Best overall
Made using micronized, certified USP Estriol, this is a great hormone-replacement treatment addressing symptoms of menopause. Manufactured in an FDA-registered facility, this is the most reliably safe, and, boasting a 90-day money-back guarantee with third-party testing, Estro-Life is sure to offer relief.
This treatment is also suitable for people with allergies, as it is gluten-free, dairy-free, soy-free, and phenoxyethanol-free, and is made from a plant-based hormone. Animal lovers will love this cruelty-free offering.
Estro-Life Pros and Cons
Pros
- Made in FDA-registered facility
- Dairy, gluten, and soy free
- Safe for allergies
- Third-party tested
- 90-day money-back guarantee
- Cruelty-free (no animal testing)
Cons
- May cause headaches
Best for balance


Bring balance to your life
Buy NowContainer size
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3.38oz or 5oz
Price
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$19 or $23
Therapy type
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Hormone replacement
This progesterone-based cream offers a 90-day money-back guarantee, is plant-based (made using Wild Yams), and provides 50% more progesterone per bottle than similar brands.
Most reviews for this product are glowing, reporting significant assistance in weight management, better sleep, and superb regulation of periods.
Pro-Relief Balancing Cream Pros and Cons
Pros
- Can assist weight loss
- Regulates periods
- Better sleep
- 90-day money-back guarantee
- Provides 50% more progesterone
- Plant-based
- Cruelty-free (no animal testing)
Cons
- May cause rashes
Best for vaginal discomfort
Created by experts in the field, this cream for vaginal issues is known for its delicate care. Made with organic ingredients, and carefully designed to be gentle, it is free from chemicals, fragrances, and anything that may cause discomfort.
Proven to provide relief from itching, burning, and dryness, and can help heal skin tears while balancing PH levels.
Premium Natural Vulvacare Pros and Cons
Pros
- Created by medical professionals
- Gentle and non-irritant
- Organic
Cons
- No expiration date listed
Best for sensitive skin
Recommended by dermatologists and gynecologists, this is a safe, non-irritating cream for relief from vaginal dryness, pain, and itching. Numerous women reported significant healing effects after only a few days.
This treatment is GMO, fragrance, soy, steroid, synthetic preservative, petroleum, and paraben-free. However, it does contain honey, which might cause issues in diabetic women or those prone to yeast infections.
Vmagic Pros and Cons
Pros
- Prebiotic
- Antioxidant
- Anti-inflammatory
- Recommended by dermatologists and gynecologists
- Organic
Cons
- Contains honey
Safest option
Many women experienced unpleasant side effects from hormone replacement therapy. This natural and third-party-tested cream contains progesterone to stabilize menstrual cycles, improve mood, and relieve symptoms of menopause. Like most of our selected products, it is free from paraben, GMOs, propylene glycol, phenoxyethanol, soy, gluten, and dairy.
In most cases, women showed positive results after only a few days of treatment.
Progresto-Life Pros and Cons
Pros
- Works fast
- Manufactured in an FDA-registered facility
- Cruelty-free (no animal testing)
- 90-day money-back guarantee
- Third-party tested
Cons
-
Best vegan option
Vegan women with vaginal dryness who are prone to UTIs and yeast infections will love this offering from Joellyne Naturals. Balancing estrogen levels with vegan phytoestrogen, an excellent estrogen mimic, this cream provides fantastic relief. It is enriched with ginseng, green tea, and red clover, as well as shea butter and coconut oil for skin enhancement.
This product is also GMO, gluten, and sulfate-free.
Estrogen Cream for Menopause Relief Pros and Cons
Pros
- Vegan
- Improves moisture in sensitive areas
- Boosts libido
- More phytoestrogen than other competitors
- Pleasant smell
Cons
- May cause rashes
Best Value for money


Find relief at low cost
Buy NowContainer sizes
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1oz, 2oz, 3oz, or 4oz
Price
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$17, $22, $28, or $26
Therapy type
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Hormone replacement
This menopause relief cream is a fantastically budget-friendly option for women needing to balance their hormones. It provides measured doses of 20mg of progesterone per pump and is lab-verified and paraben-free.
Ingredients include aloe, sunflower seeds, and shea butter.
Progesta-Care Pros and Cons
Pros
- Regulates menstrual cycle
- Measured doses
- Attractive price
- Cruelty-free (no animal testing)
Cons
- Potentially ineffective pumping mechanism
Best for hot flashes
Created under official Good Manufacturing Practices (GMP) by members of the NSF International, this is a cost-effective cream known for improving symptoms of perimenopause and menopause, especially hot flashes. Like most of our other products, it is paraben-free.
Wild Yam Cream Pros and Cons
Pros
- Reduces severity and number of hot flashes
- Effective for women in perimenopause
- Clinically tested
Cons
- Unpleasant smell
Best hormone-free option
This hormone-free menopause relief cream is specially formulated to nourish dry and irritated skin, reduce atrophy, and increase elasticity.
Created using seaberry oil and hyaluronate, this cream is clinically-tested and has shown proven efficacy in relieving unpleasant vaginal symptoms for numerous menopausal women.
Intimate Moisture Cream Pros and Cons
Pros
- Clinically tested
- Hormone-free
- Reduces itching & burning
- Maintains the normal pH balance
- Contains hyaluronic acid
Cons
- No instructions on packaging
- Pricier than other options
Best for mood support
NOW Solutions’ menopause treatment cream provides 65 pumps of 20 mg of progesterone per bottle, in either a lavender scent or fragrance-free, both of which received excellent reviews.
Inspired and created using natural products, cruelty-free and GMP certified, this is a great all-rounder product.
Progesterone from Wild Yam by NOW Solutions
Pros
- Affordable
- Treats a range of symptoms
- Cruelty-free (no animal testing)
- Pleasant scent
Cons
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Final Verdict: Which Product Is the Best?
Each of these menopause creams has something great to offer, treating symptoms uniquely. Many of these treatments show the same type of efficacy as prescription medication, without the side effects. Intimate Moisture Cream by Membrasin is a wonderful hormone-free option, while Progesta-Care by Life-Flo offers remarkable value for money. Our overall favorite is Estro-Life by SM Nutrition, with its attractive money-back guarantee and treatment of various symptoms. We hope one of these ten creams will suit you as an individual, and make a positive difference in treating your symptoms.