Femara (Letrozole) vs. Clomid: Which Is Better for Fertility?

Femara/Letrozole and Clomid aid in fertility by inducing ovulation. Here, we look at the side effects and success rate of Femara vs Clomid and compare the two.

By Toni Henning
Edited by Taj Schlebusch

Published November 23, 2021.

If you are trying to fall pregnant, your doctor may prescribe Femara (Letrozole) or Clomid to aid fertility. Both medicines are taken orally for up to a maximum of six cycles. They are prescribed to induce ovulation. In this article, we support you by looking at the side effects and success rate of Femara (Letrozole) vs. Clomid as fertility treatment options.

Letrozole vs. Clomid Benefits

Although Femara (Letrozole) is used for treating breast cancer, it can also be prescribed to improve ovulation by blocking estrogen production. This causes the body to release higher than normal levels of follicle-stimulating hormone (FSH), which stimulates the ovarian follicles to develop and mature in the ovary.

Clomid works similarly by blocking estrogen receptors. This makes your body believe that estrogen levels are low, stimulating the production of FSH.

When it comes to inducing ovulation, Letrozole (Femara) is very slightly more effective than using Clomid for fertility.

In the debate between Letrozole vs. Clomid for fertility, Letrozole has a higher pregnancy rate, that is, 61% success compared to Clomid at 43%. Women with a lower BMI exhibit higher rates of success. When couples include Intrauterine insemination (IUI) with Letrozole or Clomid treatments, the chances of pregnancy increase.

In addition, Letrozole has more positive outcomes when compared to Clomid when used in the treatment of unexplained infertility.

Letrozole vs. Clomid Side Effects

Both fertility medications have side effects, including:

  • Abdominal bloating
  • Hot flashes
  • Headaches
  • Weight fluctuation

Final Verdict: Which One Should You Take?

Even though Letrozole (Famara) costs more than Clomid, the fact that Letrozole has fewer side effects and a higher success rate means that it is our number one choice.